William M Grady Selected Research

Transforming Growth Factor-beta Type II Receptor

1/2017	Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.
6/2015	Polymerase Slippage Restoration of Frameshifted TGFBR2 in Colorectal Cancer: A Novel Paradigm.
1/2012	Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss.
9/2010	TGF-beta inactivation and TGF-alpha overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer.
5/2009	TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
2/2008	Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells.
10/2006	Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.
2/2006	Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.
4/2005	Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.
7/2004	Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

William M Grady Research Topics

Disease

46	Neoplasms (Cancer) 12/2022 - 01/2004
36	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 07/2008
23	Colonic Neoplasms (Colon Cancer) 12/2022 - 01/2004
12	Adenocarcinoma 01/2022 - 07/2004
8	Polyps 12/2021 - 02/2005
6	Barrett Esophagus (Barrett's Esophagus) 12/2020 - 01/2014
6	Carcinogenesis 10/2020 - 01/2002
6	Adenoma (Adenomas) 08/2009 - 07/2004
4	Intestinal Neoplasms (Intestinal Cancer) 01/2017 - 10/2006
4	Microsatellite Instability 01/2016 - 02/2006
4	Genomic Instability 10/2008 - 01/2002
3	Neoplasm Metastasis (Metastasis) 01/2017 - 05/2009
2	Rectal Neoplasms (Rectal Cancer) 07/2021 - 11/2015
2	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2021 - 01/2021
2	Disease Progression 10/2020 - 06/2012
2	Colitis 01/2020 - 08/2014
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020 - 08/2014
2	Inflammation (Inflammations) 01/2019 - 08/2014
2	Metaplasia 01/2018 - 06/2015
2	Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer) 01/2016 - 05/2007
2	Liver Neoplasms (Liver Cancer) 01/2012 - 09/2010
1	Prostatic Neoplasms (Prostate Cancer) 01/2022
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 10/2020
1	Neoplasm Micrometastasis 10/2020
1	Vitamin D Deficiency 01/2020
1	Weight Gain 01/2020
1	Colitis-Associated Neoplasms 01/2020
1	Rett Syndrome (Rett's Disorder) 01/2017
1	Nervous System Diseases (Neurological Disorders) 01/2017
1	Heartburn (Pyrosis) 01/2016
1	Esophageal Neoplasms (Esophageal Cancer) 01/2014
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2014

Drug/Important Bio-Agent (IBA)

21	Biomarkers (Surrogate Marker)IBA 12/2022 - 08/2009
12	Transforming Growth Factor-beta Type II ReceptorIBA 01/2017 - 01/2002
12	Transforming Growth Factor beta (TGF-beta)IBA 01/2017 - 07/2004
10	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 02/2005
6	Irinotecan (Camptosar)FDA LinkGeneric 12/2022 - 08/2013
6	Calcibiotic Root Canal SealerIBA 12/2021 - 08/2009
6	Proteins (Proteins, Gene)FDA Link 01/2018 - 04/2005
6	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 09/2010 - 07/2004
4	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 08/2010
4	AcidsIBA 01/2018 - 01/2014
4	Biological ProductsIBA 01/2017 - 07/2008
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 07/2004
3	MicroRNAs (MicroRNA)IBA 10/2017 - 06/2010
2	A-Form DNA (A-DNA)IBA 01/2022 - 01/2021
2	CytokinesIBA 10/2021 - 10/2008
2	ChromatinIBA 01/2021 - 10/2008
2	Untranslated RNA (Noncoding RNA)IBA 01/2021 - 10/2015
2	Pharmaceutical PreparationsIBA 01/2021 - 10/2020
2	Vitamin D FDA LinkGeneric 01/2020 - 08/2014
2	CateninsIBA 01/2018 - 01/2017
2	Leucovorin (Folinic Acid)FDA Link 01/2016 - 09/2014
2	Fluorouracil (Carac)FDA LinkGeneric 01/2016 - 09/2014
2	CarcinogensIBA 12/2010 - 10/2008
2	AzoxymethaneIBA 01/2010 - 07/2004
2	Cyclin D1IBA 05/2009 - 02/2006
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 07/2008 - 10/2006
2	polyadenineIBA 02/2008 - 02/2006
2	Tumor Suppressor Protein p14ARF (p14ARF)IBA 05/2007 - 08/2006
1	CreatinineIBA 01/2022
1	CarbonIBA 01/2022
1	Vitamin B 6IBA 01/2022
1	Toll-Like Receptor 4IBA 10/2021
1	Peptides (Polypeptides)IBA 12/2020
1	TubulinIBA 12/2020
1	4-aminobenzoylglutamic acidIBA 10/2020
1	Sulindac (Copal)FDA LinkGeneric 10/2020
1	N-(4-acetamidobenzoyl)-L-glutamic acidIBA 10/2020
1	Eflornithine (Ornidyl)FDA Link 10/2020
1	CalciumIBA 01/2020
1	hydroxide ionIBA 01/2020
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2020
1	Dextrans (Dextran)FDA Link 01/2020
1	Biological FactorsIBA 01/2019
1	C-Reactive ProteinIBA 01/2019
1	Cell-Free Nucleic AcidsIBA 11/2018
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2018
1	Hormones (Hormone)IBA 01/2018
1	GTP Phosphohydrolases (GTPases)IBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2017
1	Messenger RNA (mRNA)IBA 09/2016
1	TropomyosinIBA 09/2016
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2016
1	Capecitabine (Xeloda)FDA Link 01/2016
1	XELOXIBA 01/2016
1	Histones (Histone)IBA 10/2015
1	DNA Repair EnzymesIBA 08/2013
1	EnzymesIBA 08/2013
1	RecQ HelicasesIBA 08/2013
1	ORALIT (ORS)IBA 05/2013
1	LigandsIBA 01/2013

Therapy/Procedure

13	Therapeutics 12/2022 - 10/2008
7	Drug Therapy (Chemotherapy) 01/2017 - 01/2004
2	Chemoprevention 01/2021 - 08/2020
1	Prostatectomy (Retropubic Prostatectomy) 01/2022
1	Neoadjuvant Therapy 07/2021
1	Colectomy 10/2020
1	Aftercare (After-Treatment) 01/2017
1	Radiotherapy 11/2015